Personalized virtual heart models have demonstrated increasing potential for clinical use, although the estimation of their parameters given patient-specific data remain a challenge. Traditional physics-based modeling approaches are computationally costly and often neglect the inherent structural errors in these models due to model simplifications and assumptions. Modern deep learning approaches, on the other hand, rely heavily on data supervision and lacks interpretability. In this paper, we present a novel hybrid modeling framework to describe a personalized cardiac digital twin as a combination of a physics-based known expression augmented by neural network modeling of its unknown gap to reality. We then present a novel meta-learning framework to enable the separate identification of both the physics-based and neural components in the hybrid model. We demonstrate the feasibility and generality of this hybrid modeling framework with two examples of instantiations and their proof-of-concept in synthetic experiments.

Automatic speech recognition (ASR) systems typically rely on an external endpointer (EP) model to identify speech boundaries. In this work, we propose a method to jointly train the ASR and EP tasks in a single end-to-end (E2E) multitask model, improving EP quality by optionally leveraging information from the ASR audio encoder. We introduce a "switch" connection, which trains the EP to consume either the audio frames directly or low-level latent representations from the ASR model. This results in a single E2E model that can be used during inference to perform frame filtering at low cost, and also make high quality end-of-query (EOQ) predictions based on ongoing ASR computation. We present results on a voice search test set showing that, compared to separate single-task models, this approach reduces median endpoint latency by 120 ms (30.8% reduction), and 90th percentile latency by 170 ms (23.0% reduction), without regressing word error rate. For continuous recognition, WER improves by 10.6% (relative).

A Machine can only learn if it is biased in some way. Typically the bias is supplied by hand, for example through the choice of an appropriate set of features. However, if the learning machine is embedded within an {\em environment} of related tasks, then it can {\em learn} its own bias by learning sufficiently many tasks from the environment. In this paper two models of bias learning (or equivalently, learning to learn) are introduced and the main theoretical results presented. The first model is a PAC-type model based on empirical process theory, while the second is a hierarchical Bayes model.